Cell Senescence Entries for RBPJ

Cell Types
Esophageal keratinocyte
Cell Lines
EPC1-hTERT, EPC2-hTERT
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Kagawa et al. (2015) Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene 34(18)2347-59 (PubMed)

RBPJ Gene Information

HGNC symbol
RBPJ 
Aliases
CBF1; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJK; RBPSUH; SUH 
Common name
recombination signal binding protein for immunoglobulin kappa J region 
Entrez Id
3516
Description
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013].

RBPJ Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:45892; negative regulation of transcription, DNA-templated
GO:7219; Notch signaling pathway
GO:120163; negative regulation of cold-induced thermogenesis
GO:122; negative regulation of transcription by RNA polymerase II
GO:30513; positive regulation of BMP signaling pathway
GO:3151; outflow tract morphogenesis
GO:1525; angiogenesis
And 53 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:785; chromatin
GO:17053; transcription repressor complex
GO:2193; MAML1-RBP-Jkappa- ICN1 complex
GO:5667; transcription regulator complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:3682; chromatin binding
GO:47485; protein N-terminus binding
And 1 more GO terms
Show all GO terms

Homologs of RBPJ in Model Organisms

Caenorhabditis elegans
lag-1
Danio rerio
rbpja
Drosophila melanogaster
Su(H)
Mus musculus
Rbpj
Rattus norvegicus
Rbpj
Schizosaccharomyces pombe
cbf11

External links

OMIM
147183
Ensembl
ENSG00000168214
Entrez Gene
3516
UniGene
479396
1000 Genomes
1000 Genomes
HPRD
GenAtlas
RBPJ
GeneCards
RBPJ