Cell Senescence Entries for RNASEH2A
- Cell Types
- Cervical cancer
- Cell Lines
- HeLa
- Cancer Cell?
- Yes
- Method
- Knockout
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Wang et al. (2019) Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. Oncogene 38(14)2451-2463 (PubMed)
RNASEH2A Gene Information
- HGNC symbol
- RNASEH2A
- Aliases
- AGS4; RNASEHI; RNHIA; RNHL
- Common name
- ribonuclease H2 subunit A
- Entrez Id
- 10535
- Description
- The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
RNASEH2A Ontologies
- Gene Ontology
-
Process: GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:90501; RNA phosphodiester bond hydrolysis
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:16070; RNA metabolic process
GO:6260; DNA replication
GO:6401; RNA catabolic process
GO:43137; DNA replication, removal of RNA primer
GO:6298; mismatch repair
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:32299; ribonuclease H2 complex
Show all GO termsFunction: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:4518; nuclease activity
GO:4519; endonuclease activity
GO:4523; RNA-DNA hybrid ribonuclease activity
GO:4540; ribonuclease activity
Homologs of RNASEH2A in Model Organisms
- Caenorhabditis elegans
- rnh-2
- Danio rerio
- rnaseh2a
- Drosophila melanogaster
- CG13690
- Mus musculus
- Rnaseh2a
- Rattus norvegicus
- Rnaseh2a
- Saccharomyces cerevisiae
- RNH201
- Schizosaccharomyces pombe
- rnh201
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RNH201
- CellAge gene expression
- This gene is present as RNASEH2A
External links
- OMIM
- 606034
- Ensembl
- ENSG00000104889
- Entrez Gene
- 10535
- UniGene
- 532851
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RNASEH2A
- GeneCards
- RNASEH2A