Cell Senescence Entries for RNASEH2B
- Cell Types
- Cervical cancer
- Cell Lines
- HeLa
- Cancer Cell?
- Yes
- Method
- Knockout
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Wang et al. (2019) Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. Oncogene 38(14)2451-2463 (PubMed)
RNASEH2B Gene Information
- HGNC symbol
- RNASEH2B
- Aliases
- AGS2; DLEU8; FLJ11712
- Common name
- ribonuclease H2 subunit B
- Entrez Id
- 79621
- Description
- RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008].
RNASEH2B Ontologies
- Gene Ontology
-
Process: GO:6401; RNA catabolic process
GO:6298; mismatch repair
GO:9259; ribonucleotide metabolic process
GO:1701; in utero embryonic development
GO:10389; regulation of G2/M transition of mitotic cell cycle
GO:10629; negative regulation of gene expression
GO:48146; positive regulation of fibroblast proliferation
GO:2000001; regulation of DNA damage checkpoint
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:32299; ribonuclease H2 complex
Show all GO termsFunction:
Homologs of RNASEH2B in Model Organisms
- Caenorhabditis elegans
- CELE_F21D5.6
- Danio rerio
- rnaseh2b
- Drosophila melanogaster
- CG11164
- Mus musculus
- Rnaseh2b
- Rattus norvegicus
- Rnaseh2b
External links
- OMIM
- 610326
- Ensembl
- ENSG00000136104
- Entrez Gene
- 79621
- UniGene
- 306291
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RNASEH2B
- GeneCards
- RNASEH2B