Cell Senescence Entries for RRM1
- Cell Types
- Colorectal cancer
- Cell Lines
- HCT116
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)
RRM1 Gene Information
- HGNC symbol
- RRM1
- Aliases
- Common name
- ribonucleotide reductase catalytic subunit M1
- Entrez Id
- 6240
- Description
- This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
RRM1 Ontologies
- Gene Ontology
-
Process: GO:8152; metabolic process
GO:6260; DNA replication
GO:6264; mitochondrial DNA replication
GO:6281; DNA repair
GO:9185; ribonucleoside diphosphate metabolic process
GO:9263; deoxyribonucleotide biosynthetic process
GO:9265; 2'-deoxyribonucleotide biosynthetic process
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:51290; protein heterotetramerization
GO:70318; positive regulation of G0 to G1 transition
GO:1900087; positive regulation of G1/S transition of mitotic cell cycle
And 2 more GO terms Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:5971; ribonucleoside-diphosphate reductase complex
GO:16020; membrane
GO:16021; integral component of membrane
Show all GO termsFunction: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16491; oxidoreductase activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:4748; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:17076; purine nucleotide binding
GO:61731; ribonucleoside-diphosphate reductase activity
GO:97718; disordered domain specific binding
Homologs of RRM1 in Model Organisms
- Caenorhabditis elegans
- rnr-1
- Danio rerio
- rrm1
- Drosophila melanogaster
- RnrL
- Mus musculus
- Rrm1
- Rattus norvegicus
- Rrm1
- Saccharomyces cerevisiae
- RNR1
- Schizosaccharomyces pombe
- cdc22
In other databases
- CellAge gene expression
- This gene is present as RRM1
External links
- OMIM
- 180410
- Ensembl
- ENSG00000167325
- Entrez Gene
- 6240
- UniGene
- 445705
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- RRM1
- GeneCards
- RRM1