Cell Senescence Entries for SENP7
- Cell Types
- Foreskin fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Yates et al. (2008) Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell 7(5)609-21 (PubMed)
SENP7 Gene Information
- HGNC symbol
- SENP7
- Aliases
- Common name
- SUMO specific peptidase 7
- Entrez Id
- 57337
- Description
- The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009].
SENP7 Ontologies
- Gene Ontology
-
Process: GO:6508; proteolysis
GO:16926; protein desumoylation
GO:140374; antiviral innate immune response
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
Show all GO termsFunction: GO:8233; peptidase activity
GO:8234; cysteine-type peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:70139; SUMO-specific endopeptidase activity
Homologs of SENP7 in Model Organisms
- Danio rerio
- si:dkey-100n23.3
- Mus musculus
- Senp7
- Rattus norvegicus
- Senp7
External links
- OMIM
- 612846
- Ensembl
- ENSG00000138468
- Entrez Gene
- 57337
- UniGene
- 529551
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SENP7
- GeneCards
- SENP7