Cell Senescence Entries for SETD1A

Cell Types
Breast cancer, Colorectal cancer
Cell Lines
DLD1, H630, HCT116, HCT15, HCT8, HT29, MDA-MB-231, SW620
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Tajima et al. (2019) SETD1A protects from senescence through regulation of the mitotic gene expression program. Nat Commun 10(1)2854 (PubMed)

SETD1A Gene Information

HGNC symbol
SETD1A 
Aliases
KIAA0339; KMT2F; Set1; SET1A 
Common name
SET domain containing 1A, histone lysine methyltransferase 
Entrez Id
9739
Description
The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016].

SETD1A Ontologies

Gene Ontology
Process: GO:32259; methylation
GO:6325; chromatin organization
GO:6974; cellular response to DNA damage stimulus
GO:51568; histone H3-K4 methylation
GO:7420; brain development
GO:44648; histone H3-K4 dimethylation
GO:80182; histone H3-K4 trimethylation
GO:97692; histone H3-K4 monomethylation
GO:1902036; regulation of hematopoietic stem cell differentiation
GO:1902275; regulation of chromatin organization
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5694; chromosome
GO:48188; Set1C/COMPASS complex
GO:5654; nucleoplasm
GO:35097; histone methyltransferase complex
GO:785; chromatin
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:5515; protein binding
GO:18024; histone-lysine N-methyltransferase activity
GO:42800; histone methyltransferase activity (H3-K4 specific)
GO:42054; histone methyltransferase activity
GO:8013; beta-catenin binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
Show all GO terms

Homologs of SETD1A in Model Organisms

Caenorhabditis elegans
set-2
Danio rerio
setd1a
Mus musculus
Setd1a
Rattus norvegicus
uncharacterized_F1LP

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as set-2

External links

OMIM
611052
Ensembl
ENSG00000099381
Entrez Gene
9739
UniGene
297483
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SETD1A
GeneCards
SETD1A