Cell Senescence Entries for SFN

Cell Types
Melanoma
Cell Lines
SK-MEL-147, SK-MEL-19, SK-MEL-29
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Schultz et al. (2009) 14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescence. Mol Cancer 8(2)53 (PubMed)

SFN Gene Information

HGNC symbol
SFN 
Aliases
YWHAS 
Common name
stratifin 
Entrez Id
2810
Description
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017].

SFN Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:34613; cellular protein localization
GO:45606; positive regulation of epidermal cell differentiation
GO:61436; establishment of skin barrier
GO:1836; release of cytochrome c from mitochondria
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:79; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:3334; keratinocyte development
GO:6469; negative regulation of protein kinase activity
GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:10482; regulation of epidermal cell division
And 8 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:5615; extracellular space
Function: GO:5515; protein binding
GO:19901; protein kinase binding
GO:42802; identical protein binding
GO:45296; cadherin binding
GO:8426; protein kinase C inhibitor activity
GO:51219; phosphoprotein binding
Show all GO terms

Homologs of SFN in Model Organisms

Mus musculus
Sfn
Rattus norvegicus
Sfn

External links

OMIM
601290
Ensembl
ENSG00000175793
Entrez Gene
2810
UniGene
523718
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SFN
GeneCards
SFN