Cell Senescence Entries for SFRP1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Elzi et al. (2013) Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Mol Cell Biol 32(21)4388-99 (PubMed)

SFRP1 Gene Information

HGNC symbol
SFRP1 
Aliases
FRP; FRP-1; SARP2 
Common name
secreted frizzled related protein 1 
Entrez Id
6422
Description
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009].

SFRP1 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:16055; Wnt signaling pathway
GO:6508; proteolysis
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:10629; negative regulation of gene expression
GO:30177; positive regulation of Wnt signaling pathway
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:90263; positive regulation of canonical Wnt signaling pathway
And 84 more GO terms
Cellular component: GO:5615; extracellular space
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5829; cytosol
GO:9986; cell surface
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
Function: GO:5515; protein binding
GO:8201; heparin binding
GO:4197; cysteine-type endopeptidase activity
GO:17147; Wnt-protein binding
GO:5109; frizzled binding
GO:42802; identical protein binding
Show all GO terms

Homologs of SFRP1 in Model Organisms

Mus musculus
Sfrp1

In other databases

CellAge gene expression
  • This gene is present as SFRP1

External links

OMIM
604156
Ensembl
ENSG00000104332
Entrez Gene
6422
UniGene
213424
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SFRP1
GeneCards
SFRP1