Cell Senescence Entries for SIN3B
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockout, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Grandinetti et al. (2009) Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress. Cancer Res 69(16)6430-7 (PubMed)
SIN3B Gene Information
- HGNC symbol
- SIN3B
- Aliases
- KIAA0700
- Common name
- SIN3 transcription regulator family member B
- Entrez Id
- 23309
- Description
SIN3B Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:16575; histone deacetylation
GO:45892; negative regulation of transcription, DNA-templated
GO:30336; negative regulation of cell migration
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:118; histone deacetylase complex
GO:805; X chromosome
GO:806; Y chromosome
GO:1741; XY body
GO:5737; cytoplasm
GO:16580; Sin3 complex
GO:30849; autosome
Show all GO termsFunction: GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:3682; chromatin binding
Homologs of SIN3B in Model Organisms
External links
- OMIM
- 607777
- Ensembl
- ENSG00000127511
- Entrez Gene
- 23309
- UniGene
- 13999
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SIN3B
- GeneCards
- SIN3B