Cell Senescence Entries for SIRT7

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Aljada et al. (2015) Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance. Diagn Pathol 9(2)94 (PubMed)

SIRT7 Gene Information

HGNC symbol
SIRT7 
Aliases
 
Common name
sirtuin 7 
Entrez Id
51547
Description
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008].

SIRT7 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6476; protein deacetylation
GO:61699; peptidyl-lysine deglutarylation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:7129; homologous chromosome pairing at meiosis
GO:10529; negative regulation of transposition
GO:10821; regulation of mitochondrion organization
GO:31397; negative regulation of protein ubiquitination
And 18 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:785; chromatin
GO:5694; chromosome
GO:5730; nucleolus
GO:35861; site of double-strand break
GO:5731; nucleolus organizer region
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:70403; NAD+ binding
GO:34979; NAD-dependent protein deacetylase activity
GO:36055; protein-succinyllysine desuccinylase activity
GO:61697; protein-glutaryllysine deglutarylase activity
GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:3682; chromatin binding
GO:19213; deacetylase activity
GO:4407; histone deacetylase activity
And 3 more GO terms
Show all GO terms

Homologs of SIRT7 in Model Organisms

Danio rerio
sirt7
Mus musculus
Sirt7
Rattus norvegicus
Sirt7

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Sirt7
GenAge human genes
  • This gene is present as SIRT7

External links

OMIM
606212
Ensembl
ENSG00000187531
Entrez Gene
51547
UniGene
514636
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SIRT7
GeneCards
SIRT7