Cell Senescence Entries for SKP2

Cell Types
Prostate cancer
Cell Lines
DU145, PC-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Lin et al. (2010) Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature 464(7287)374-9 (PubMed)

SKP2 Gene Information

HGNC symbol
SKP2 
Aliases
FBL1; FBXL1; p45 
Common name
S-phase kinase associated protein 2 
Entrez Id
6502
Description
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011].

SKP2 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:70936; protein K48-linked ubiquitination
GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:86; G2/M transition of mitotic cell cycle
GO:51726; regulation of cell cycle
GO:42981; regulation of apoptotic process
GO:82; G1/S transition of mitotic cell cycle
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:19005; SCF ubiquitin ligase complex
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:16301; kinase activity
Show all GO terms

Homologs of SKP2 in Model Organisms

Caenorhabditis elegans
skpt-1
Danio rerio
skp2
Drosophila melanogaster
Skp2
Mus musculus
Skp2
Rattus norvegicus
Skp2

In other databases

CellAge gene expression
  • This gene is present as SKP2

External links

OMIM
601436
Ensembl
ENSG00000145604
Entrez Gene
6502
UniGene
23348
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SKP2
GeneCards
SKP2