Cell Senescence Entries for SLC16A7

Cell Types
Colon cancer, Gastric cancer
Cell Lines
DLD1, HCT116, HCT8, HT29, LoVo, MKN45, MKN74, SW480
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2013) Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo. Mol Cancer Ther 11(11)2342-51 (PubMed)

SLC16A7 Gene Information

HGNC symbol
SLC16A7 
Aliases
MCT2 
Common name
solute carrier family 16 member 7 
Entrez Id
9194
Description
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

SLC16A7 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:15718; monocarboxylic acid transport
GO:1901475; pyruvate transmembrane transport
GO:150104; transport across blood-brain barrier
GO:35873; lactate transmembrane transport
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
Function: GO:22857; transmembrane transporter activity
GO:15293; symporter activity
GO:8028; monocarboxylic acid transmembrane transporter activity
GO:5515; protein binding
GO:5477; pyruvate secondary active transmembrane transporter activity
GO:15129; lactate transmembrane transporter activity
GO:50833; pyruvate transmembrane transporter activity
Show all GO terms

Homologs of SLC16A7 in Model Organisms

Danio rerio
zgc:165507
Mus musculus
Slc16a7
Rattus norvegicus
Slc16a7

External links

OMIM
603654
Ensembl
ENSG00000118596
Entrez Gene
9194
UniGene
439643
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SLC16A7
GeneCards
SLC16A7