Cell Senescence Entries for SMAD1

Cell Types
Lung cancer
Cell Lines
NCI-H460
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Su et al. (2011) Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung cancer cells. Biochem J 433(2)333-43 (PubMed)

SMAD1 Gene Information

HGNC symbol
SMAD1 
Aliases
JV4-1; MADH1; MADR1 
Common name
SMAD family member 1 
Entrez Id
4086
Description
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].

SMAD1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:7179; transforming growth factor beta receptor signaling pathway
GO:10628; positive regulation of gene expression
GO:7165; signal transduction
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:30509; BMP signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:60395; SMAD protein signal transduction
GO:1901522; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1903672; positive regulation of sprouting angiogenesis
And 28 more GO terms
Cellular component: GO:5634; nucleus
GO:5667; transcription regulator complex
GO:5737; cytoplasm
GO:16021; integral component of membrane
GO:5637; nuclear inner membrane
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
GO:32991; protein-containing complex
GO:71144; heteromeric SMAD protein complex
GO:71141; SMAD protein complex
And 2 more GO terms
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3700; DNA-binding transcription factor activity
GO:70410; co-SMAD binding
GO:70411; I-SMAD binding
And 4 more GO terms
Show all GO terms

Homologs of SMAD1 in Model Organisms

Danio rerio
smad1
Mus musculus
Smad1
Rattus norvegicus
Smad1

External links

OMIM
601595
Ensembl
ENSG00000170365
Entrez Gene
4086
UniGene
604588
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMAD1
GeneCards
SMAD1