Cell Senescence Entries for SMARCD1

Cell Types
Fetal lung fibroblast, Liver cancer
Cell Lines
Hep G2, TIG-1
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Inoue et al. (2020) SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes. NPJ Aging Mech Dis 3(2)11 (PubMed)

SMARCD1 Gene Information

HGNC symbol
SMARCD1 
Aliases
BAF60A; CRACD1; Rsc6p 
Common name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 
Entrez Id
6602
Description
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

SMARCD1 Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:45893; positive regulation of transcription, DNA-templated
GO:7399; nervous system development
GO:6338; chromatin remodeling
GO:6357; regulation of transcription by RNA polymerase II
GO:6337; nucleosome disassembly
GO:45815; positive regulation of gene expression, epigenetic
GO:2000045; regulation of G1/S transition of mitotic cell cycle
GO:2000781; positive regulation of double-strand break repair
GO:71398; cellular response to fatty acid
GO:30071; regulation of mitotic metaphase/anaphase transition
And 9 more GO terms
Cellular component: GO:5634; nucleus
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:16514; SWI/SNF complex
GO:71564; npBAF complex
GO:71565; nBAF complex
GO:785; chromatin
GO:776; kinetochore
GO:35060; brahma complex
GO:16363; nuclear matrix
GO:16586; RSC-type complex
And 2 more GO terms
Function: GO:5515; protein binding
GO:3712; transcription coregulator activity
GO:3713; transcription coactivator activity
GO:60090; molecular adaptor activity
GO:3682; chromatin binding
GO:5102; signaling receptor binding
Show all GO terms

Homologs of SMARCD1 in Model Organisms

Danio rerio
smarcd1
Mus musculus
Smarcd1
Rattus norvegicus
Smarcd1

External links

OMIM
601735
Ensembl
ENSG00000066117
Entrez Gene
6602
UniGene
79335
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMARCD1
GeneCards
SMARCD1