Cell Senescence Entries for SMC1A

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Andriani et al. (2018) Whole Chromosome Instability induces senescence and promotes SASP. Sci Rep 6(2)35218 (PubMed)

SMC1A Gene Information

HGNC symbol
SMC1A 
Aliases
DXS423E; KIAA0178; SB1.8; SMC1L1; Smcb 
Common name
structural maintenance of chromosomes 1A 
Entrez Id
8243
Description
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].

SMC1A Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6281; DNA repair
GO:51276; chromosome organization
GO:51321; meiotic cell cycle
GO:7062; sister chromatid cohesion
GO:7064; mitotic sister chromatid cohesion
GO:51301; cell division
GO:6974; cellular response to DNA damage stimulus
GO:19827; stem cell population maintenance
GO:90307; mitotic spindle assembly
GO:9314; response to radiation
And 4 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5694; chromosome
GO:8278; cohesin complex
GO:775; chromosome, centromeric region
GO:776; kinetochore
GO:16363; nuclear matrix
GO:30893; meiotic cohesin complex
GO:97431; mitotic spindle pole
GO:794; condensed nuclear chromosome
And 2 more GO terms
Function: GO:5524; ATP binding
GO:16887; ATP hydrolysis activity
GO:3682; chromatin binding
GO:5515; protein binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:3677; DNA binding
GO:36033; mediator complex binding
GO:46982; protein heterodimerization activity
Show all GO terms

Homologs of SMC1A in Model Organisms

Danio rerio
smc1a
Mus musculus
Smc1a
Rattus norvegicus
Smc1a

External links

OMIM
300040
Ensembl
ENSG00000072501
Entrez Gene
8243
UniGene
211602
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SMC1A
GeneCards
SMC1A