Cell Senescence Entries for SOD1

Cell Types
Lung fibroblast
Cell Lines
WI-38, WI38-SV40
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Blander et al. (2003) Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J Biol Chem 278(40)38966-9 (PubMed)

SOD1 Gene Information

HGNC symbol
SOD1 
Aliases
ALS; ALS1; IPOA 
Common name
superoxide dismutase 1 
Entrez Id
6647
Description
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020].

SOD1 Ontologies

Gene Ontology
Process: GO:6801; superoxide metabolic process
GO:19430; removal of superoxide radicals
GO:7605; sensory perception of sound
GO:43065; positive regulation of apoptotic process
GO:6879; cellular iron ion homeostasis
GO:10033; response to organic substance
GO:7283; spermatogenesis
GO:6749; glutathione metabolic process
GO:43085; positive regulation of catalytic activity
GO:72593; reactive oxygen species metabolic process
GO:1890; placenta development
And 54 more GO terms
Cellular component: GO:5654; nucleoplasm
GO:5829; cytosol
GO:5634; nucleus
GO:5737; cytoplasm
GO:31410; cytoplasmic vesicle
GO:32991; protein-containing complex
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5615; extracellular space
GO:1904115; axon cytoplasm
And 11 more GO terms
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:4784; superoxide dismutase activity
GO:8270; zinc ion binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:16209; antioxidant activity
GO:5507; copper ion binding
GO:31267; small GTPase binding
GO:51087; chaperone binding
GO:19899; enzyme binding
And 2 more GO terms
Show all GO terms

Homologs of SOD1 in Model Organisms

Caenorhabditis elegans
sod-5
Danio rerio
sod1
Drosophila melanogaster
Sod
Mus musculus
Sod1
Rattus norvegicus
Sod1
Saccharomyces cerevisiae
SOD1
Schizosaccharomyces pombe
sod1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
  • A homolog of this gene for Drosophila melanogaster is present as Sod
GenAge human genes
  • This gene is present as SOD1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
LongevityMap
  • This gene is present as SOD1

External links

OMIM
147450
Ensembl
ENSG00000142168
Entrez Gene
6647
UniGene
443914
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SOD1
GeneCards
SOD1