Cell Senescence Entries for SOX1

Cell Types
Liver cancer
Cell Lines
Hep3B
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Tsao et al. (2013) SOX1 functions as a tumor suppressor by antagonizing the WNT/β-catenin signaling pathway in hepatocellular carcinoma. Hepatology 56(6)2277-87 (PubMed)

SOX1 Gene Information

HGNC symbol
SOX1 
Aliases
 
Common name
SRY-box transcription factor 1 
Entrez Id
6656
Description
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008].

SOX1 Ontologies

Gene Ontology
Process: GO:7399; nervous system development
GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1764; neuron migration
GO:2089; lens morphogenesis in camera-type eye
GO:21521; ventral spinal cord interneuron specification
GO:21879; forebrain neuron differentiation
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of SOX1 in Model Organisms

Danio rerio
sox1a
Mus musculus
Sox1

External links

OMIM
602148
Ensembl
ENSG00000182968
Entrez Gene
6656
UniGene
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SOX1
GeneCards
SOX1