Cell Senescence Entries for SOX4

Cell Types
Squamous carcinoma
Cell Lines
KYSE-410, KYSE-510
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Han et al. (2020) Upregulation of SOX4 antagonizes cellular senescence in esophageal squamous cell carcinoma. Oncol Lett 12(2)1367-1372 (PubMed)

SOX4 Gene Information

HGNC symbol
SOX4 
Aliases
 
Common name
SRY-box transcription factor 4 
Entrez Id
6659
Description
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008].

SOX4 Ontologies

Gene Ontology
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:8285; negative regulation of cell population proliferation
GO:30154; cell differentiation
GO:9653; anatomical structure morphogenesis
GO:1501; skeletal system development
GO:6355; regulation of transcription, DNA-templated
GO:8284; positive regulation of cell population proliferation
GO:31647; regulation of protein stability
GO:21510; spinal cord development
And 34 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:785; chromatin
GO:5667; transcription regulator complex
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:35198; miRNA binding
Show all GO terms

Homologs of SOX4 in Model Organisms

Danio rerio
sox4a
Mus musculus
Sox4

In other databases

CellAge gene expression
  • This gene is present as SOX4

External links

OMIM
184430
Ensembl
ENSG00000124766
Entrez Gene
6659
UniGene
643910
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SOX4
GeneCards
SOX4