Cell Senescence Entries for SP1

Cell Types
Lung fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Wu et al. (2010) Sp1 is essential for p16 expression in human diploid fibroblasts during senescence. PLoS One 2(1)e164 (PubMed)

SP1 Gene Information

HGNC symbol
SP1 
Aliases
 
Common name
Sp1 transcription factor 
Entrez Id
6667
Description
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014].

SP1 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:6357; regulation of transcription by RNA polymerase II
GO:45766; positive regulation of angiogenesis
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:1902004; positive regulation of amyloid-beta formation
GO:43923; positive regulation by host of viral transcription
And 4 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:785; chromatin
GO:791; euchromatin
GO:17053; transcription repressor complex
GO:32993; protein-DNA complex
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1990837; sequence-specific double-stranded DNA binding
And 12 more GO terms
Show all GO terms

Homologs of SP1 in Model Organisms

Danio rerio
sp1
Mus musculus
Sp1
Rattus norvegicus
Sp1

In other databases

GenAge human genes
  • This gene is present as SP1

External links

OMIM
189906
Ensembl
ENSG00000185591
Entrez Gene
6667
UniGene
649191
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SP1
GeneCards
SP1