Cell Senescence Entries for SPI1

Cell Types
Foreskin fibroblast, Hematopoietic stem progenitor, Lung fibroblast
Cell Lines
BJ, Primary cell, WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Delestré et al. (2018) Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells. Haematologica 102(11)1850-1860 (PubMed)

SPI1 Gene Information

HGNC symbol
SPI1 
Aliases
OF; PU.1; SFPI1; SPI-1; SPI-A 
Common name
Spi-1 proto-oncogene 
Entrez Id
6688
Description
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

SPI1 Ontologies

Gene Ontology
Process: GO:10629; negative regulation of gene expression
GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45892; negative regulation of transcription, DNA-templated
GO:43966; histone H3 acetylation
GO:30154; cell differentiation
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:2357; defense response to tumor cell
GO:45814; negative regulation of gene expression, epigenetic
And 41 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:5667; transcription regulator complex
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:97677; STAT family protein binding
GO:140297; DNA-binding transcription factor binding
GO:1216; DNA-binding transcription activator activity
And 10 more GO terms
Show all GO terms

Homologs of SPI1 in Model Organisms

Danio rerio
spi1b
Mus musculus
Spi1
Rattus norvegicus
Spi1

External links

OMIM
165170
Ensembl
ENSG00000066336
Entrez Gene
6688
UniGene
502511
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SPI1
GeneCards
SPI1