Cell Senescence Entries for SPOP
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown, Mutation, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Zhu et al. (2016) SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. Cell Rep 13(6)1183-1193 (PubMed)
SPOP Gene Information
- HGNC symbol
- SPOP
- Aliases
- BTBD32; TEF2
- Common name
- speckle type BTB/POZ protein
- Entrez Id
- 8405
- Description
- This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
SPOP Ontologies
- Gene Ontology
-
Process: GO:16567; protein ubiquitination
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:209; protein polyubiquitination
GO:30162; regulation of proteolysis
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:31463; Cul3-RING ubiquitin ligase complex
Show all GO termsFunction: GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
Homologs of SPOP in Model Organisms
External links
- OMIM
- 602650
- Ensembl
- ENSG00000121067
- Entrez Gene
- 8405
- UniGene
- 740407
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SPOP
- GeneCards
- SPOP