Cell Senescence Entries for SRF

Cell Types
Coronary artery smooth muscle
Cell Lines
Primary cell
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Werth et al. (2010) Proliferation of human primary vascular smooth muscle cells depends on serum response factor. Eur J Cell Biol 89(2-3)216-24 (PubMed)

SRF Gene Information

HGNC symbol
SRF 
Aliases
MCM1 
Common name
serum response factor 
Entrez Id
6722
Description
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].

SRF Ontologies

Gene Ontology
Process: GO:30036; actin cytoskeleton organization
GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48513; animal organ development
GO:1569; branching involved in blood vessel morphogenesis
GO:1701; in utero embryonic development
GO:1707; mesoderm formation
GO:1764; neuron migration
GO:1947; heart looping
GO:2011; morphogenesis of an epithelial sheet
GO:2042; cell migration involved in sprouting angiogenesis
And 70 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:3700; DNA-binding transcription factor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:10736; serum response element binding
And 9 more GO terms
Show all GO terms

Homologs of SRF in Model Organisms

Danio rerio
srf
Drosophila melanogaster
bs
Mus musculus
Srf
Rattus norvegicus
Srf

External links

OMIM
600589
Ensembl
ENSG00000112658
Entrez Gene
6722
UniGene
520140
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SRF
GeneCards
SRF