Cell Senescence Entries for SRSF3

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Tang et al. (2013) Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence. Oncogene 32(22)2792-8 (PubMed)

SRSF3 Gene Information

HGNC symbol
SRSF3 
Aliases
SFRS3; SRp20 
Common name
serine and arginine rich splicing factor 3 
Entrez Id
6428
Description
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010].

SRSF3 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:51028; mRNA transport
GO:6406; mRNA export from nucleus
GO:398; mRNA splicing, via spliceosome
GO:1990830; cellular response to leukemia inhibitory factor
GO:48024; regulation of mRNA splicing, via spliceosome
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5515; protein binding
GO:43274; phospholipase binding
Show all GO terms

Homologs of SRSF3 in Model Organisms

Caenorhabditis elegans
rsp-6
Danio rerio
srsf3b
Mus musculus
Srsf3
Rattus norvegicus
Srsf3

In other databases

CellAge gene expression
  • This gene is present as SRSF3

External links

OMIM
603364
Ensembl
ENSG00000112081
Entrez Gene
6428
UniGene
405144
1000 Genomes
1000 Genomes
HPRD
GenAtlas
SRSF3
GeneCards
SRSF3