Cell Senescence Entries for TACC3
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockout
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Schmidt et al. (2011) The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. Oncogene 29(46)6184-92 (PubMed)
TACC3 Gene Information
- HGNC symbol
- TACC3
- Aliases
- ERIC-1; ERIC1; maskin; Tacc4
- Common name
- transforming acidic coiled-coil containing protein 3
- Entrez Id
- 10460
- Description
- This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011].
TACC3 Ontologies
- Gene Ontology
-
Process: GO:7052; mitotic spindle organization
GO:7049; cell cycle
GO:51301; cell division
GO:226; microtubule cytoskeleton organization
GO:8283; cell population proliferation
GO:21987; cerebral cortex development
GO:60236; regulation of mitotic spindle organization
GO:1902850; microtubule cytoskeleton organization involved in mitosis
GO:7091; metaphase/anaphase transition of mitotic cell cycle
Cellular component: GO:43231; intracellular membrane-bounded organelle
GO:5829; cytosol
GO:72686; mitotic spindle
GO:34451; centriolar satellite
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5815; microtubule organizing center
GO:5819; spindle
GO:922; spindle pole
Function: GO:5515; protein binding
Homologs of TACC3 in Model Organisms
In other databases
- CellAge gene expression
- This gene is present as TACC3
External links
- OMIM
- 605303
- Ensembl
- ENSG00000013810
- Entrez Gene
- 10460
- UniGene
- 104019
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TACC3
- GeneCards
- TACC3