Cell Senescence Entries for TBX3

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Kumar P et al. (2015) Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife 3(2)117-26 (PubMed)

TBX3 Gene Information

HGNC symbol
TBX3 
Aliases
TBX3-ISO; UMS; XHL 
Common name
T-box transcription factor 3 
Entrez Id
6926
Description
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].

TBX3 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:1568; blood vessel development
GO:1701; in utero embryonic development
GO:1947; heart looping
GO:3007; heart morphogenesis
GO:3151; outflow tract morphogenesis
GO:3167; atrioventricular bundle cell differentiation
GO:7569; cell aging
And 49 more GO terms
Cellular component: GO:5634; nucleus
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Show all GO terms

Homologs of TBX3 in Model Organisms

Danio rerio
tbx3a
Drosophila melanogaster
bi
Mus musculus
Tbx3
Rattus norvegicus
Tbx3

External links

OMIM
601621
Ensembl
ENSG00000135111
Entrez Gene
6926
UniGene
744016
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TBX3
GeneCards
TBX3