Cell Senescence Entries for TEAD4

Cell Types
Gastric cancer
Cell Lines
MGC-803, MKN28, SGC-7901
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Zhou et al. (2017) TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis. Oncogene 36(47)6518-6530 (PubMed)

TEAD4 Gene Information

HGNC symbol
TEAD4 
Aliases
EFTR-2; RTEF-1; TCF13L1; TEF-3; TEFR-1 
Common name
TEA domain transcription factor 4 
Entrez Id
7004
Description
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008].

TEAD4 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:35329; hippo signaling
GO:6351; transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:1501; skeletal system development
GO:7517; muscle organ development
GO:48568; embryonic organ development
GO:1701; in utero embryonic development
GO:1708; cell fate specification
GO:1825; blastocyst formation
GO:1830; trophectodermal cell fate commitment
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:5667; transcription regulator complex
GO:5737; cytoplasm
GO:32993; protein-DNA complex
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of TEAD4 in Model Organisms

Mus musculus
Tead4
Rattus norvegicus
LOC683522

External links

OMIM
601714
Ensembl
ENSG00000197905
Entrez Gene
7004
UniGene
94865
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TEAD4
GeneCards
TEAD4