Cell Senescence Entries for TGFB1I1

Cell Types
Fibroblast
Cell Lines
KMST-6, SUSM-1
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Shibanuma et al. (1997) Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts. Mol Cell Biol 17(3)1224-35 (PubMed)

TGFB1I1 Gene Information

HGNC symbol
TGFB1I1 
Aliases
ARA55; Hic-5; TSC-5 
Common name
transforming growth factor beta 1 induced transcript 1 
Entrez Id
7041
Description
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

TGFB1I1 Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:16055; Wnt signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:7155; cell adhesion
GO:8285; negative regulation of cell population proliferation
GO:30511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:16331; morphogenesis of embryonic epithelium
GO:30579; ubiquitin-dependent SMAD protein catabolic process
GO:30855; epithelial cell differentiation
And 3 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:30054; cell junction
GO:5886; plasma membrane
GO:5829; cytosol
GO:16363; nuclear matrix
GO:62023; collagen-containing extracellular matrix
Function: GO:46872; metal ion binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:3712; transcription coregulator activity
GO:70411; I-SMAD binding
GO:48495; Roundabout binding
GO:50681; androgen receptor binding
Show all GO terms

Homologs of TGFB1I1 in Model Organisms

Caenorhabditis elegans
pxl-1
Mus musculus
Tgfb1i1
Rattus norvegicus
Tgfb1i1

External links

OMIM
602353
Ensembl
ENSG00000140682
Entrez Gene
7041
UniGene
513530
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TGFB1I1
GeneCards
TGFB1I1