Cell Senescence Entries for TGFBR1

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)

TGFBR1 Gene Information

HGNC symbol
TGFBR1 
Aliases
ACVRLK4; ALK-5; ALK5; ESS1; MSSE; TBR-i; TBRI 
Common name
transforming growth factor beta receptor 1 
Entrez Id
7046
Description
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

TGFBR1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7178; transmembrane receptor protein serine/threonine kinase signaling pathway
GO:10628; positive regulation of gene expression
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:30154; cell differentiation
GO:80090; regulation of primary metabolic process
GO:40008; regulation of growth
GO:18105; peptidyl-serine phosphorylation
GO:51726; regulation of cell cycle
GO:51171; regulation of nitrogen compound metabolic process
And 75 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5634; nucleus
GO:5768; endosome
GO:30054; cell junction
GO:45121; membrane raft
GO:9986; cell surface
GO:5923; bicellular tight junction
GO:43235; receptor complex
GO:48179; activin receptor complex
And 2 more GO terms
Function: GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:4675; transmembrane receptor protein serine/threonine kinase activity
GO:43167; ion binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:4672; protein kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:5025; transforming growth factor beta receptor activity, type I
And 10 more GO terms
Show all GO terms

Homologs of TGFBR1 in Model Organisms

Danio rerio
tgfbr1b
Mus musculus
Tgfbr1
Rattus norvegicus
Tgfbr1

External links

OMIM
190181
Ensembl
ENSG00000106799
Entrez Gene
7046
UniGene
494622
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TGFBR1
GeneCards
TGFBR1