Cell Senescence Entries for TGFBR2

Cell Types
Lung cancer, Lung fibroblast
Cell Lines
A549, IMR-90, MCF-7, SK-HEP-1
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Unclear
Primary Reference
Rapisarda et al. (2017) Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway. Cell Rep 18(10)2480-2493 (PubMed)
Cell Types
Lung cancer, Lung fibroblast
Cell Lines
A549, IMR-90, MCF-7, SK-HEP-1
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Unclear
Primary Reference
Gao et al. (2019) Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition. Nat Commun 10(1)1665 (PubMed)

TGFBR2 Gene Information

HGNC symbol
TGFBR2 
Aliases
MFS2; TBR-ii; TBRII 
Common name
transforming growth factor beta receptor 2 
Entrez Id
7048
Description
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017].

TGFBR2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:30154; cell differentiation
GO:40008; regulation of growth
GO:7178; transmembrane receptor protein serine/threonine kinase signaling pathway
GO:51239; regulation of multicellular organismal process
GO:1569; branching involved in blood vessel morphogenesis
GO:1570; vasculogenesis
GO:1666; response to hypoxia
GO:1701; in utero embryonic development
And 78 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:45121; membrane raft
GO:5829; cytosol
GO:5737; cytoplasm
GO:5887; integral component of plasma membrane
GO:5901; caveola
GO:9897; external side of plasma membrane
GO:9986; cell surface
GO:43235; receptor complex
And 2 more GO terms
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:38023; signaling receptor activity
GO:4675; transmembrane receptor protein serine/threonine kinase activity
GO:5024; transforming growth factor beta-activated receptor activity
And 10 more GO terms
Show all GO terms

Homologs of TGFBR2 in Model Organisms

Caenorhabditis elegans
daf-4
Danio rerio
tgfbr2
Mus musculus
Tgfbr2
Rattus norvegicus
Tgfbr2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-4

External links

OMIM
190182
Ensembl
ENSG00000163513
Entrez Gene
7048
UniGene
604277
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TGFBR2
GeneCards
TGFBR2