Cell Senescence Entries for TIGAR

Cell Types
T-cell cancer
Cell Lines
HuT102, KOB, ST1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Hasegawa et al. (2009) Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells. Leukemia 23(11)2090-101 (PubMed)

TIGAR Gene Information

HGNC symbol
TIGAR 
Aliases
C12orf5 
Common name
TP53 induced glycolysis regulatory phosphatase 
Entrez Id
57103
Description
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008].

TIGAR Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:6974; cellular response to DNA damage stimulus
GO:6914; autophagy
GO:16311; dephosphorylation
GO:45739; positive regulation of DNA repair
GO:30388; fructose 1,6-bisphosphate metabolic process
GO:2931; response to ischemia
GO:71456; cellular response to hypoxia
GO:6003; fructose 2,6-bisphosphate metabolic process
GO:43069; negative regulation of programmed cell death
GO:43456; regulation of pentose-phosphate shunt
And 13 more GO terms
Cellular component: GO:5829; cytosol
GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
Function: GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:5515; protein binding
GO:4331; fructose-2,6-bisphosphate 2-phosphatase activity
GO:4083; bisphosphoglycerate 2-phosphatase activity
Show all GO terms

Homologs of TIGAR in Model Organisms

Danio rerio
tigarb
Mus musculus
Tigar
Rattus norvegicus
LOC502894

In other databases

CellAge gene expression
  • This gene is present as TIGAR

External links

OMIM
610775
Ensembl
ENSG00000078237
Entrez Gene
57103
UniGene
504545
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TIGAR
GeneCards
TIGAR