The TLR2 gene and its putative association with human ageing

Cell Senescence Entries for TLR2

Cell Types: Embryonic kidney, Lung fibroblast
Cell Lines: HEK293T, IMR-90
Cancer Cell?: No
Method: Knockdown, Overexpression
Type of senescence: Oncogene-induced
Senescence Effect: Induces
Primary Reference: Hari et al. (2020) The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv 5(6)eaaw0254 (PubMed)

TLR2 Gene Information

HGNC symbol: TLR2
Aliases: CD282; TIL4
Common name: toll like receptor 2
Entrez Id: 7097
Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

TLR2 Ontologies

Gene Ontology

Process:

GO:50896; response to stimulus
GO:45087; innate immune response
GO:6955; immune response
GO:1817; regulation of cytokine production
GO:2224; toll-like receptor signaling pathway
GO:2755; MyD88-dependent toll-like receptor signaling pathway
GO:2237; response to molecule of bacterial origin
GO:34134; toll-like receptor 2 signaling pathway
GO:50729; positive regulation of inflammatory response
GO:7165; signal transduction
GO:2376; immune system process

And 50 more GO terms

Cellular component:	GO:16021; integral component of membrane GO:5737; cytoplasm GO:16020; membrane GO:5794; Golgi apparatus GO:31410; cytoplasmic vesicle GO:45121; membrane raft GO:9986; cell surface GO:30670; phagocytic vesicle membrane GO:5886; plasma membrane GO:5887; integral component of plasma membrane GO:43235; receptor complex
	And 7 more GO terms

Function:

GO:4888; transmembrane signaling receptor activity
GO:5515; protein binding
GO:16787; hydrolase activity
GO:3953; NAD+ nucleosidase activity
GO:42802; identical protein binding
GO:50135; NAD(P)+ nucleosidase activity
GO:61809; NAD+ nucleotidase, cyclic ADP-ribose generating
GO:38023; signaling receptor activity
GO:1530; lipopolysaccharide binding
GO:1540; amyloid-beta binding
GO:1875; lipopolysaccharide immune receptor activity

And 7 more GO terms

Show all GO terms

Homologs of TLR2 in Model Organisms

Danio rerio: tlr2
Drosophila melanogaster: Toll-9
Mus musculus: Tlr2
Rattus norvegicus: Tlr2

Cell Senescence Entries for TLR2

TLR2 Gene Information

TLR2 Ontologies

Homologs of TLR2 in Model Organisms

External links