Cell Senescence Entries for TOP3A
- Cell Types
- Colon cancer
- Cell Lines
- AGS
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Hsieh et al. (2014) DNA topoisomerase III alpha regulates p53-mediated tumor suppression. Clin Cancer Res 20(6)1489-501 (PubMed)
TOP3A Gene Information
- HGNC symbol
- TOP3A
- Aliases
- TOP3; ZGRF7
- Common name
- DNA topoisomerase III alpha
- Entrez Id
- 7156
- Description
- This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
TOP3A Ontologies
- Gene Ontology
-
Process: GO:6265; DNA topological change
GO:51321; meiotic cell cycle
GO:51304; chromosome separation
GO:32042; mitochondrial DNA metabolic process
GO:724; double-strand break repair via homologous recombination
GO:71139; resolution of recombination intermediates
Cellular component: GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5694; chromosome
GO:16605; PML body
GO:5634; nucleus
GO:5654; nucleoplasm
GO:31422; RecQ family helicase-topoisomerase III complex
Show all GO termsFunction: GO:3676; nucleic acid binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16853; isomerase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:3916; DNA topoisomerase activity
GO:3917; DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:3697; single-stranded DNA binding
Homologs of TOP3A in Model Organisms
- Caenorhabditis elegans
- top-3
- Danio rerio
- top3a
- Drosophila melanogaster
- Top3alpha
- Mus musculus
- Top3a
- Rattus norvegicus
- Top3a
- Saccharomyces cerevisiae
- TOP3
- Schizosaccharomyces pombe
- top3
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Top3alpha
External links
- OMIM
- 601243
- Ensembl
- ENSG00000177302
- Entrez Gene
- 7156
- UniGene
- 713037
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TOP3A
- GeneCards
- TOP3A