Cell Senescence Entries for TOPBP1

Cell Types
Cervical cancer, Foreskin fibroblast, Lung fibroblast, Osteosarcoma
Cell Lines
HeLa, HS68, IMR-90, U2OS
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Inhibits
Primary Reference
Jeon et al. (2011) TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells. J Biol Chem 286(7)5414-22 (PubMed)

TOPBP1 Gene Information

HGNC symbol
TOPBP1 
Aliases
Dpb11; KIAA0259; TOP2BP1 
Common name
DNA topoisomerase II binding protein 1 
Entrez Id
11073
Description
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].

TOPBP1 Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:10212; response to ionizing radiation
GO:6259; DNA metabolic process
GO:6270; DNA replication initiation
GO:33314; mitotic DNA replication checkpoint signaling
GO:7095; mitotic G2 DNA damage checkpoint signaling
GO:35825; homologous recombination
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5694; chromosome
GO:16604; nuclear body
GO:15629; actin cytoskeleton
GO:16605; PML body
GO:5815; microtubule organizing center
And 6 more GO terms
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:8022; protein C-terminus binding
Show all GO terms

Homologs of TOPBP1 in Model Organisms

Caenorhabditis elegans
mus-101
Danio rerio
topbp1
Drosophila melanogaster
mus101
Mus musculus
Topbp1
Rattus norvegicus
Topbp1

In other databases

CellAge gene expression
  • This gene is present as TOPBP1

External links

OMIM
607760
Ensembl
ENSG00000163781
Entrez Gene
11073
UniGene
593379
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TOPBP1
GeneCards
TOPBP1