Cell Senescence Entries for TRDMT1
- Cell Types
- Foreskin fibroblast, Lung fibroblast
- Cell Lines
- BJ, WI-38
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Lewinska et al. (2018) Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression. Redox Biol 14(2)20-34 (PubMed)
TRDMT1 Gene Information
- HGNC symbol
- TRDMT1
- Aliases
- DNMT2; RNMT1
- Common name
- tRNA aspartic acid methyltransferase 1
- Entrez Id
- 1787
- Description
- This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010].
TRDMT1 Ontologies
- Gene Ontology
-
Process: GO:32259; methylation
GO:8033; tRNA processing
GO:30488; tRNA methylation
GO:1975; response to amphetamine
GO:6400; tRNA modification
GO:36416; tRNA stabilization
Cellular component: GO:5737; cytoplasm
GO:5654; nucleoplasm
Show all GO termsFunction: GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:3723; RNA binding
GO:8175; tRNA methyltransferase activity
GO:16428; tRNA (cytosine-5-)-methyltransferase activity
Homologs of TRDMT1 in Model Organisms
- Danio rerio
- trdmt1
- Drosophila melanogaster
- Mt2
- Mus musculus
- Trdmt1
- Rattus norvegicus
- Trdmt1
- Schizosaccharomyces pombe
- pmt1
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Mt2
External links
- OMIM
- 602478
- Ensembl
- ENSG00000107614
- Entrez Gene
- 1787
- UniGene
- 564140
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TRDMT1
- GeneCards
- TRDMT1