Cell Senescence Entries for TRIM28

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Santos et al. (2015) TRIM28/KAP1 regulates senescence. Immunol Lett 162(1 Pt B)281-9 (PubMed)

TRIM28 Gene Information

HGNC symbol
TRIM28 
Aliases
KAP1; PPP1R157; RNF96; TF1B; TIF1B 
Common name
tripartite motif containing 28 
Entrez Id
10155
Description
The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008].

TRIM28 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:16567; protein ubiquitination
GO:6281; DNA repair
GO:45087; innate immune response
GO:16925; protein sumoylation
GO:45739; positive regulation of DNA repair
GO:7265; Ras protein signal transduction
GO:45893; positive regulation of transcription, DNA-templated
GO:42307; positive regulation of protein import into nucleus
GO:44790; negative regulation by host of viral release from host cell
And 15 more GO terms
Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:90575; RNA polymerase II transcription regulator complex
GO:785; chromatin
GO:791; euchromatin
GO:792; heterochromatin
Function: GO:3723; RNA binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:4842; ubiquitin-protein transferase activity
GO:3713; transcription coactivator activity
GO:3682; chromatin binding
And 6 more GO terms
Show all GO terms

Homologs of TRIM28 in Model Organisms

Mus musculus
Trim28
Rattus norvegicus
Trim28

In other databases

CellAge gene expression
  • This gene is present as TRIM28

External links

OMIM
601742
Ensembl
ENSG00000130726
Entrez Gene
10155
UniGene
467408
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TRIM28
GeneCards
TRIM28