Cell Senescence Entries for TTK
- Cell Types
- Liver cancer
- Cell Lines
- Hep G2, Huh7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Miao et al. (2018) Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer. Sci Rep 6(2)33121 (PubMed)
TTK Gene Information
- HGNC symbol
- TTK
- Aliases
- CT96; MPH1; MPS1; MPS1L1
- Common name
- TTK protein kinase
- Entrez Id
- 7272
- Description
- This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
TTK Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:51304; chromosome separation
GO:18105; peptidyl-serine phosphorylation
GO:7094; mitotic spindle assembly checkpoint signaling
GO:7059; chromosome segregation
GO:8284; positive regulation of cell population proliferation
GO:10862; positive regulation of pathway-restricted SMAD protein phosphorylation
GO:7051; spindle organization
GO:7052; mitotic spindle organization
GO:33316; meiotic spindle assembly checkpoint signaling
And 9 more GO terms Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5634; nucleus
GO:5819; spindle
GO:776; kinetochore
Show all GO termsFunction: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:42802; identical protein binding
And 2 more GO terms
Homologs of TTK in Model Organisms
- Danio rerio
- ttk
- Drosophila melanogaster
- ald
- Mus musculus
- Ttk
- Rattus norvegicus
- Ttk
- Schizosaccharomyces pombe
- ppk1
In other databases
- CellAge gene expression
- This gene is present as TTK
External links
- OMIM
- 604092
- Ensembl
- ENSG00000112742
- Entrez Gene
- 7272
- UniGene
- 169840
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TTK
- GeneCards
- TTK