Cell Senescence Entries for UHRF1

Cell Types
Lung fibroblast, Osteosarcoma
Cell Lines
2BS, IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Yang et al. (2017) PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311. Oncogene 36(34)4828-4842 (PubMed)

UHRF1 Gene Information

HGNC symbol
UHRF1 
Aliases
FLJ21925; ICBP90; Np95; RNF106; TDRD22 
Common name
ubiquitin like with PHD and ring finger domains 1 
Entrez Id
29128
Description
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014].

UHRF1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16567; protein ubiquitination
GO:6325; chromatin organization
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:122; negative regulation of transcription by RNA polymerase II
GO:51865; protein autoubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:32270; positive regulation of cellular protein metabolic process
GO:10390; histone monoubiquitination
And 5 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
GO:792; heterochromatin
GO:16363; nuclear matrix
GO:5657; replication fork
GO:791; euchromatin
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:4842; ubiquitin-protein transferase activity
GO:35064; methylated histone binding
GO:61630; ubiquitin protein ligase activity
GO:42393; histone binding
GO:42802; identical protein binding
GO:8327; methyl-CpG binding
And 4 more GO terms
Show all GO terms

Homologs of UHRF1 in Model Organisms

Danio rerio
uhrf1
Mus musculus
Uhrf1
Rattus norvegicus
Uhrf1

In other databases

CellAge gene expression
  • This gene is present as UHRF1

External links

OMIM
607990
Ensembl
ENSG00000276043
Entrez Gene
29128
UniGene
108106
1000 Genomes
1000 Genomes
HPRD
GenAtlas
UHRF1
GeneCards
UHRF1