Cell Senescence Entries for VEGFA
- Cell Types
- Dermal endothelial
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Watanabe et al. (1997) Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene 14(17)2025-32 (PubMed)
VEGFA Gene Information
- HGNC symbol
- VEGFA
- Aliases
- VEGF; VEGF-A; VPF
- Common name
- vascular endothelial growth factor A
- Entrez Id
- 7422
- Description
- This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. [provided by RefSeq, Jun 2020].
VEGFA Ontologies
- Gene Ontology
-
Process: GO:10629; negative regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:30154; cell differentiation
GO:1934; positive regulation of protein phosphorylation
GO:7399; nervous system development
GO:51781; positive regulation of cell division
GO:1525; angiogenesis
GO:8284; positive regulation of cell population proliferation
GO:45766; positive regulation of angiogenesis
GO:10628; positive regulation of gene expression
And 103 more GO terms Cellular component: GO:5615; extracellular space
GO:5737; cytoplasm
GO:16020; membrane
GO:5576; extracellular region
GO:31012; extracellular matrix
GO:9986; cell surface
GO:31093; platelet alpha granule lumen
GO:30141; secretory granule
GO:5912; adherens junction
Show all GO termsFunction: GO:8083; growth factor activity
GO:5515; protein binding
GO:8201; heparin binding
GO:48018; receptor ligand activity
GO:42802; identical protein binding
GO:42803; protein homodimerization activity
GO:5125; cytokine activity
GO:42056; chemoattractant activity
GO:5172; vascular endothelial growth factor receptor binding
GO:43184; vascular endothelial growth factor receptor 2 binding
GO:5161; platelet-derived growth factor receptor binding
And 5 more GO terms
Homologs of VEGFA in Model Organisms
In other databases
External links
- OMIM
- 192240
- Ensembl
- ENSG00000112715
- Entrez Gene
- 7422
- UniGene
- 73793
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- VEGFA
- GeneCards
- VEGFA