Cell Senescence Entries for XAF1
- Cell Types
- Dermal microvascular endothelial
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown, Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Heo et al. (2017) XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. Oncotarget 7(5)5118-30 (PubMed)
XAF1 Gene Information
- HGNC symbol
- XAF1
- Aliases
- BIRC4BP; HSXIAPAF1; XIAPAF1
- Common name
- XIAP associated factor 1
- Entrez Id
- 54739
- Description
- This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
XAF1 Ontologies
- Gene Ontology
-
Process: GO:6915; apoptotic process
GO:35456; response to interferon-beta
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5829; cytosol
Show all GO termsFunction: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:5515; protein binding
Homologs of XAF1 in Model Organisms
External links
- OMIM
- 606717
- Ensembl
- ENSG00000132530
- Entrez Gene
- 54739
- UniGene
- 441975
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- XAF1
- GeneCards
- XAF1