Cell Senescence Entries for XPC

Cell Types
Glioblastoma
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Liu et al. (2010) XPC silencing sensitizes glioma cells to arsenic trioxide via increased oxidative damage. Toxicol Sci 116(1)183-93 (PubMed)

XPC Gene Information

HGNC symbol
XPC 
Aliases
RAD4; XPCC 
Common name
XPC complex subunit, DNA damage recognition and repair factor 
Entrez Id
7508
Description
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017].

XPC Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45893; positive regulation of transcription, DNA-templated
GO:6289; nucleotide-excision repair
GO:1901990; regulation of mitotic cell cycle phase transition
GO:6298; mismatch repair
GO:720; pyrimidine dimer repair by nucleotide-excision repair
GO:9410; response to xenobiotic stimulus
GO:10224; response to UV-B
GO:10996; response to auditory stimulus
GO:31573; mitotic intra-S DNA damage checkpoint signaling
And 3 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5694; chromosome
GO:109; nucleotide-excision repair complex
GO:71942; XPC complex
And 3 more GO terms
Function: GO:3677; DNA binding
GO:3684; damaged DNA binding
GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:3697; single-stranded DNA binding
GO:44877; protein-containing complex binding
GO:405; bubble DNA binding
GO:140612; DNA damage sensor activity
GO:404; heteroduplex DNA loop binding
Show all GO terms

Homologs of XPC in Model Organisms

Danio rerio
xpc
Mus musculus
Xpc
Rattus norvegicus
Xpc
Saccharomyces cerevisiae
RAD4

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAD4
LongevityMap
  • This gene is present as XPC

External links

OMIM
613208
Ensembl
ENSG00000154767
Entrez Gene
7508
UniGene
739296
1000 Genomes
1000 Genomes
HPRD
GenAtlas
XPC
GeneCards
XPC