Cell Senescence Entries for YEATS4
- Cell Types
- Bronchial epithelial, Lung cancer
- Cell Lines
- H1355, H1993, H226, HBEC-KT, HBEC-KT53
- Cancer Cell?
- Yes
- Method
- Knockdown, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Pikor et al. (2014) YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway. Cancer Res 73(24)7301-12 (PubMed)
YEATS4 Gene Information
- HGNC symbol
- YEATS4
- Aliases
- GAS41; NuBI-1; YAF9
- Common name
- YEATS domain containing 4
- Entrez Id
- 8089
- Description
- The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
YEATS4 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:7010; cytoskeleton organization
GO:45893; positive regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6357; regulation of transcription by RNA polymerase II
GO:6338; chromatin remodeling
GO:16573; histone acetylation
GO:43968; histone H2A acetylation
GO:43967; histone H4 acetylation
GO:278; mitotic cell cycle
And 6 more GO terms Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:31965; nuclear membrane
GO:16363; nuclear matrix
GO:35267; NuA4 histone acetyltransferase complex
GO:786; nucleosome
Show all GO termsFunction: GO:5515; protein binding
GO:5200; structural constituent of cytoskeleton
GO:42393; histone binding
GO:8022; protein C-terminus binding
GO:70577; lysine-acetylated histone binding
GO:140030; modification-dependent protein binding
Homologs of YEATS4 in Model Organisms
- Caenorhabditis elegans
- gfl-1
- Danio rerio
- yeats4
- Drosophila melanogaster
- Gas41
- Mus musculus
- Yeats4
- Rattus norvegicus
- Yeats4
- Saccharomyces cerevisiae
- YAF9
- Schizosaccharomyces pombe
- yaf9
In other databases
- CellAge gene expression
- This gene is present as YEATS4
External links
- OMIM
- 602116
- Ensembl
- ENSG00000127337
- Entrez Gene
- 8089
- UniGene
- 4029
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- YEATS4
- GeneCards
- YEATS4