Cell Senescence Entries for YY1

Cell Types
Lung cancer
Cell Lines
NCI-H460
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Wang et al. (2008) YY1 restrained cell senescence through repressing the transcription of p16. Biochim Biophys Acta 1783(10)1876-83 (PubMed)

YY1 Gene Information

HGNC symbol
YY1 
Aliases
DELTA; INO80S; NF-E1; UCRBP; YIN-YANG-1 
Common name
YY1 transcription factor 
Entrez Id
7528
Description
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008].

YY1 Ontologies

Gene Ontology
Process: GO:30154; cell differentiation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6310; DNA recombination
GO:122; negative regulation of transcription by RNA polymerase II
GO:7283; spermatogenesis
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:724; double-strand break repair via homologous recombination
GO:34644; cellular response to UV
And 29 more GO terms
Cellular component: GO:5634; nucleus
GO:31011; Ino80 complex
GO:16363; nuclear matrix
GO:5667; transcription regulator complex
GO:5654; nucleoplasm
GO:31519; PcG protein complex
GO:785; chromatin
GO:5677; chromatin silencing complex
GO:5737; cytoplasm
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:400; four-way junction DNA binding
And 8 more GO terms
Show all GO terms

Homologs of YY1 in Model Organisms

Danio rerio
yy1a
Drosophila melanogaster
pho
Mus musculus
Yy1
Rattus norvegicus
Yy1

In other databases

LongevityMap
  • This gene is present as YY1

External links

OMIM
600013
Ensembl
ENSG00000100811
Entrez Gene
7528
UniGene
603118
1000 Genomes
1000 Genomes
HPRD
GenAtlas
YY1
GeneCards
YY1