Cell Senescence Entries for ABCB1

Cell Types
Cervical cancer, Fibrosarcoma
Cell Lines
HeLa, HT1080
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Ruth et al. (2000) Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res 60(10)2576-8 (PubMed)

ABCB1 Gene Information

HGNC symbol
ABCB1 
Aliases
ABC20; CD243; CLCS; GP170; MDR1; p-170; P-gp; PGY1 
Common name
ATP binding cassette subfamily B member 1 
Entrez Id
5243
Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017].

ABCB1 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:6869; lipid transport
GO:150104; transport across blood-brain barrier
GO:140115; export across plasma membrane
GO:1990962; xenobiotic transport across blood-brain barrier
GO:45332; phospholipid translocation
GO:9410; response to xenobiotic stimulus
GO:86; G2/M transition of mitotic cell cycle
GO:46865; terpenoid transport
GO:47484; regulation of response to osmotic stress
GO:70633; transepithelial transport
GO:72089; stem cell proliferation
GO:99040; ceramide translocation
GO:1901529; positive regulation of anion channel activity
GO:1905039; carboxylic acid transmembrane transport
GO:1990961; xenobiotic detoxification by transmembrane export across the plasma membrane
GO:2001225; regulation of chloride transport
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:16324; apical plasma membrane
GO:70062; extracellular exosome
GO:98591; external side of apical plasma membrane
GO:9986; cell surface
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:5515; protein binding
GO:140359; ABC-type transporter activity
GO:140326; ATPase-coupled intramembrane lipid transporter activity
GO:8559; ABC-type xenobiotic transporter activity
GO:42626; ATPase-coupled transmembrane transporter activity
GO:42910; xenobiotic transmembrane transporter activity
GO:15562; efflux transmembrane transporter activity
GO:90554; phosphatidylcholine floppase activity
GO:22857; transmembrane transporter activity
GO:140328; floppase activity
GO:31625; ubiquitin protein ligase binding
GO:46943; carboxylic acid transmembrane transporter activity
GO:90555; phosphatidylethanolamine flippase activity
GO:99038; ceramide floppase activity
Hide GO terms

Homologs of ABCB1 in Model Organisms

Mus musculus
Abcb1a
Rattus norvegicus
Abcb1a

External links

OMIM
171050
Ensembl
ENSG00000085563
Entrez Gene
5243
UniGene
689936
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ABCB1
GeneCards
ABCB1