Cell Senescence Entries for ACER2

Cell Types
Lung cancer
Cell Lines
H1299
Cancer Cell?
Yes
Method
Knockout, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Xu et al. (2019) Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ 25(5)841-856 (PubMed)

ACER2 Gene Information

HGNC symbol
ACER2 
Aliases
ALKCDase2; ASAH3L; FLJ41587 
Common name
alkaline ceramidase 2 
Entrez Id
340485
Description
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010].

ACER2 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6665; sphingolipid metabolic process
GO:6974; cellular response to DNA damage stimulus
GO:6672; ceramide metabolic process
GO:8284; positive regulation of cell population proliferation
GO:42981; regulation of apoptotic process
GO:46512; sphingosine biosynthetic process
GO:10506; regulation of autophagy
GO:30148; sphingolipid biosynthetic process
GO:1953; negative regulation of cell-matrix adhesion
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:32526; response to retinoic acid
GO:10942; positive regulation of cell death
GO:33629; negative regulation of cell adhesion mediated by integrin
GO:71466; cellular response to xenobiotic stimulus
GO:46514; ceramide catabolic process
GO:90285; negative regulation of protein glycosylation in Golgi
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:139; Golgi membrane
GO:30173; integral component of Golgi membrane
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:16811; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:17040; N-acylsphingosine amidohydrolase activity
GO:102121; ceramidase activity
GO:71633; dihydroceramidase activity
Hide GO terms

Homologs of ACER2 in Model Organisms

Danio rerio
LOC100331179
Drosophila melanogaster
bwa
Mus musculus
Acer2
Rattus norvegicus
Acer2

External links

OMIM
613492
Ensembl
ENSG00000177076
Entrez Gene
340485
UniGene
99785
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ACER2
GeneCards
ACER2