Cell Senescence Entries for AGO2

Cell Types
Embryonic kidney
Cell Lines
HEK293
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Yang et al. (2014) Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence. Mol Cell 55(5)782-90 (PubMed)

AGO2 Gene Information

HGNC symbol
AGO2 
Aliases
CASC7; EIF2C2; hAGO2; LINC00980; Q10 
Common name
argonaute RISC catalytic component 2 
Entrez Id
27161
Description
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

AGO2 Ontologies

Gene Ontology
Process: GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:6412; translation
GO:6355; regulation of transcription, DNA-templated
GO:6417; regulation of translation
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:31047; gene silencing by RNA
GO:6413; translational initiation
GO:60213; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45766; positive regulation of angiogenesis
GO:30422; production of siRNA involved in RNA interference
GO:45947; negative regulation of translational initiation
GO:31054; pre-miRNA processing
GO:35196; production of miRNAs involved in gene silencing by miRNA
GO:35280; miRNA loading onto RISC involved in gene silencing by miRNA
GO:1901165; positive regulation of trophoblast cell migration
GO:35278; miRNA mediated inhibition of translation
GO:1905618; positive regulation of miRNA mediated inhibition of translation
GO:10501; RNA secondary structure unwinding
GO:16246; RNA interference
GO:35279; mRNA cleavage involved in gene silencing by miRNA
GO:9791; post-embryonic development
GO:10586; miRNA metabolic process
GO:10628; positive regulation of gene expression
GO:35087; siRNA loading onto RISC involved in RNA interference
GO:35194; post-transcriptional gene silencing by RNA
GO:42985; negative regulation of amyloid precursor protein biosynthetic process
GO:45975; positive regulation of translation, ncRNA-mediated
GO:90625; mRNA cleavage involved in gene silencing by siRNA
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5829; cytosol
GO:1990904; ribonucleoprotein complex
GO:36464; cytoplasmic ribonucleoprotein granule
GO:932; P-body
GO:16442; RISC complex
GO:5654; nucleoplasm
GO:5845; mRNA cap binding complex
GO:70578; RISC-loading complex
GO:5844; polysome
GO:70062; extracellular exosome
GO:30425; dendrite
Function: GO:35198; miRNA binding
GO:5515; protein binding
GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:3743; translation initiation factor activity
GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:4518; nuclease activity
GO:4519; endonuclease activity
GO:340; RNA 7-methylguanosine cap binding
GO:3727; single-stranded RNA binding
GO:8022; protein C-terminus binding
GO:3725; double-stranded RNA binding
GO:4521; endoribonuclease activity
GO:35197; siRNA binding
GO:993; RNA polymerase II complex binding
GO:16891; endoribonuclease activity, producing 5'-phosphomonoesters
GO:1046; core promoter sequence-specific DNA binding
GO:3729; mRNA binding
GO:70551; endoribonuclease activity, cleaving siRNA-paired mRNA
GO:90624; endoribonuclease activity, cleaving miRNA-paired mRNA
GO:98808; mRNA cap binding
Hide GO terms

Homologs of AGO2 in Model Organisms

Danio rerio
CU929240.1
Drosophila melanogaster
AGO1
Mus musculus
Eif2c2
Rattus norvegicus
Eif2c2
Schizosaccharomyces pombe
ago1

External links

OMIM
606229
Ensembl
ENSG00000123908
Entrez Gene
27161
UniGene
743313
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AGO2
GeneCards
AGO2