Cell Senescence Entries for AHR

Cell Types
Embryonic kidney
Cell Lines
HEK
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Ray et al. (2004) Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a. J Biol Chem 279(26)27187-93 (PubMed)

AHR Gene Information

HGNC symbol
AHR 
Aliases
bHLHe76 
Common name
aryl hydrocarbon receptor 
Entrez Id
196
Description
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015].

AHR Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:6805; xenobiotic metabolic process
GO:9410; response to xenobiotic stimulus
GO:7049; cell cycle
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30522; intracellular receptor signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:32922; circadian regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:19933; cAMP-mediated signaling
GO:71320; cellular response to cAMP
GO:1904613; cellular response to 2,3,7,8-tetrachlorodibenzodioxine
GO:9636; response to toxic substance
GO:1904322; cellular response to forskolin
GO:2819; regulation of adaptive immune response
GO:1568; blood vessel development
GO:2841; negative regulation of T cell mediated immune response to tumor cell
GO:10468; regulation of gene expression
GO:30888; regulation of B cell proliferation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:34751; aryl hydrocarbon receptor complex
GO:5829; cytosol
GO:785; chromatin
GO:5654; nucleoplasm
GO:32991; protein-containing complex
GO:5667; transcription regulator complex
GO:34752; cytosolic aryl hydrocarbon receptor complex
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:1990837; sequence-specific double-stranded DNA binding
GO:976; transcription cis-regulatory region binding
GO:4879; nuclear receptor activity
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:46982; protein heterodimerization activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:51879; Hsp90 protein binding
GO:70888; E-box binding
GO:17025; TBP-class protein binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:1094; TFIID-class transcription factor complex binding
GO:1223; transcription coactivator binding
Hide GO terms

Homologs of AHR in Model Organisms

Caenorhabditis elegans
ahr-1
Danio rerio
ahr1b
Drosophila melanogaster
sima
Mus musculus
Ahr
Rattus norvegicus
Ahr

External links

OMIM
600253
Ensembl
ENSG00000106546
Entrez Gene
196
UniGene
171189
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AHR
GeneCards
AHR