Cell Senescence Entries for AKAP4

Cell Types
Colon cancer
Cell Lines
COLO 205, HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Jagadish et al. (2016) A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. J Exp Clin Cancer Res 34(2)142 (PubMed)

AKAP4 Gene Information

HGNC symbol
AKAP4 
Aliases
AKAP82; CT99; Fsc1; hAKAP82; HI; p82 
Common name
A-kinase anchoring protein 4 
Entrez Id
8852
Description
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

AKAP4 Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:30030; cell projection organization
GO:30317; flagellated sperm motility
GO:7178; transmembrane receptor protein serine/threonine kinase signaling pathway
GO:8104; protein localization
GO:44458; motile cilium assembly
GO:45184; establishment of protein localization
GO:7338; single fertilization
GO:7165; signal transduction
Cellular component: GO:5634; nucleus
GO:110165; cellular anatomical entity
GO:5929; cilium
GO:31514; motile cilium
GO:42995; cell projection
GO:5737; cytoplasm
GO:30018; Z disc
GO:35686; sperm fibrous sheath
GO:48471; perinuclear region of cytoplasm
GO:97228; sperm principal piece
GO:97225; sperm midpiece
GO:5856; cytoskeleton
GO:5952; cAMP-dependent protein kinase complex
GO:97224; sperm connecting piece
GO:97229; sperm end piece
Function: GO:16301; kinase activity
GO:5515; protein binding
GO:51018; protein kinase A binding
Hide GO terms

Homologs of AKAP4 in Model Organisms

Mus musculus
Akap4
Rattus norvegicus
Akap4

External links

OMIM
300185
Ensembl
ENSG00000147081
Entrez Gene
8852
UniGene
97633
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AKAP4
GeneCards
AKAP4