Cell Senescence Entries for AKT3

Cell Types
Bladder cancer
Cell Lines
EJ138
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2017) Akt3 knockdown induces mitochondrial dysfunction in human cancer cells. Acta Biochim Biophys Sin (Shanghai) 48(5)447-53 (PubMed)

AKT3 Gene Information

HGNC symbol
AKT3 
Aliases
PKBG; PRKBG; RAC-gamma 
Common name
AKT serine/threonine kinase 3 
Entrez Id
10000
Description
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

AKT3 Ontologies

Gene Ontology
Process: GO:2000773; negative regulation of cellular senescence
GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:35556; intracellular signal transduction
GO:7165; signal transduction
GO:18105; peptidyl-serine phosphorylation
GO:1938; positive regulation of endothelial cell proliferation
GO:90050; positive regulation of cell migration involved in sprouting angiogenesis
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:2; mitochondrial genome maintenance
GO:32008; positive regulation of TOR signaling
GO:45766; positive regulation of angiogenesis
GO:45793; positive regulation of cell size
GO:48854; brain morphogenesis
GO:48873; homeostasis of number of cells within a tissue
GO:1905653; positive regulation of artery morphogenesis
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
Hide GO terms

Homologs of AKT3 in Model Organisms

Caenorhabditis elegans
akt-2
Danio rerio
akt3a
Mus musculus
Akt3
Rattus norvegicus
Akt3

In other databases

LongevityMap
  • This gene is present as AKT3

External links

OMIM
611223
Ensembl
ENSG00000117020
Entrez Gene
10000
UniGene
498292
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AKT3
GeneCards
AKT3