Cell Senescence Entries for AKTIP
- Cell Types
- Foreskin fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Primary Reference
- Burla et al. (2017) The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Open Biol 6(8)117-26 (PubMed)
AKTIP Gene Information
- HGNC symbol
- AKTIP
- Aliases
- FLJ13258; FTS
- Common name
- AKT interacting protein
- Entrez Id
- 64400
- Description
- The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
AKTIP Ontologies
- Gene Ontology
-
Process: GO:15031; protein transport
GO:6915; apoptotic process
GO:45022; early endosome to late endosome transport
GO:209; protein polyubiquitination
GO:8333; endosome to lysosome transport
GO:7040; lysosome organization
GO:7032; endosome organization
GO:1934; positive regulation of protein phosphorylation
GO:32092; positive regulation of protein binding
GO:1905719; protein localization to perinuclear region of cytoplasm
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:5634; nucleus
GO:30897; HOPS complex
GO:70695; FHF complex
Hide GO termsFunction: GO:5515; protein binding
GO:61631; ubiquitin conjugating enzyme activity
Homologs of AKTIP in Model Organisms
- Caenorhabditis elegans
- ubc-19
- Danio rerio
- aktip
- Drosophila melanogaster
- CG16894
- Mus musculus
- Aktip
- Rattus norvegicus
- Aktip
External links
- OMIM
- 608483
- Ensembl
- ENSG00000166971
- Entrez Gene
- 64400
- UniGene
- 380897
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- AKTIP
- GeneCards
- AKTIP