Cell Senescence Entries for ANXA5

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Klement et al. (2012) Accumulation of annexin A5 at the nuclear envelope is a biomarker of cellular aging. Mech Ageing Dev 133(7)508-22 (PubMed)

ANXA5 Gene Information

HGNC symbol
ANXA5 
Aliases
ANX5; ENX2 
Common name
annexin A5 
Entrez Id
308
Description
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications. [provided by RefSeq, Dec 2019].

ANXA5 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:43086; negative regulation of catalytic activity
GO:7596; blood coagulation
GO:7599; hemostasis
GO:50819; negative regulation of coagulation
GO:10033; response to organic substance
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5925; focal adhesion
GO:5576; extracellular region
GO:5829; cytosol
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:9897; external side of plasma membrane
GO:72563; endothelial microparticle
Function: GO:5509; calcium ion binding
GO:5515; protein binding
GO:5544; calcium-dependent phospholipid binding
GO:5543; phospholipid binding
GO:4859; phospholipase inhibitor activity
Hide GO terms

Homologs of ANXA5 in Model Organisms

Danio rerio
anxa5b
Mus musculus
Anxa5
Rattus norvegicus
Anxa5

In other databases

GenAge microarray genes
  • This gene is present as ANXA5

External links

OMIM
131230
Ensembl
ENSG00000164111
Entrez Gene
308
UniGene
480653
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ANXA5
GeneCards
ANXA5